Is metoprolol safe in pregnancy?

Are there any risks of taking metoprolol in pregnancy? A small number of pregnant women specifically taking metoprolol have been studied, with no concerns raised that its use causes birth defects or preterm birth. Metoprolol belongs to a family of medicines called beta blockers.

Is metoprolol safe in early pregnancy?

Metoprolol did not cause birth defects when given to animals early in pregnancy. A study of a large number of pregnancies found that beta-blockers did not cause heart defects in babies. Does taking metoprolol cause other pregnancy complications? Metoprolol has been associated with reduced growth of the baby.

Can metoprolol be used in pregnancy?

Metoprolol is a cardioselective β-adrenergic receptor antagonist used to treat pregnant women with cardiovascular diseases including hypertension, cardiomyopathy, ischemic heart disease, and arrhythmias.

Is beta-blockers safe during pregnancy?

β-Blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women. Despite the common use of this class of medication, data that support its safety are limited. β-Blockers cross the placenta and potentially can cause physiological changes in the fetus.

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What category is metoprolol in pregnancy?

Metoprolol and Pregnancy

Metoprolol falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems.

Is 50 mg of metoprolol too much?

The dose is usually 1 milligram (mg) per kilogram (kg) of body weight per day, given as a single dose. The first dose should not be more than 50 mg per day.

What is the safest beta blocker in pregnancy?

There is a general consensus that labetalol is safer than other β-blockers during pregnancy, and this drug is rapidly becoming the first-line choice in conditions, such as chronic hypertension during pregnancy.

Can beta blockers cause miscarriage?

Can taking propranolol in pregnancy cause miscarriage? A single study provided no evidence that use of propranolol in early pregnancy was linked to an increased risk of miscarriage. No further studies have assessed miscarriage rates in women taking propranolol and more research into this subject is therefore required.

Can you breastfeed while taking metoprolol?

Because of the low levels of metoprolol in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. Studies on the use of metoprolol during breastfeeding have found no adverse reactions in breastfed infants. No special precautions are required.

What does pregnancy category D mean?

Category D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Can beta-blockers cause birth defects?

Beta-blockers used to treat hypertension during the first trimester of pregnancy don’t appear to increase the risk that babies will be born with birth defects or cardiac malformations, according to an analysis of observational data on more than 18,000 women across five Nordic countries and the United States.

Why diuretics are contraindicated in pregnancy?

Diuretics given after the first trimester interfere with normal plasma volume expansion, which may exacerbate the volume depletion in pre-eclampsia and cause intrauterine growth retardation [3]. Diuretics have not been reported to have teratogenic effects.

How much aspirin is safe in pregnancy?

Aspirin can prevent blood clots, which can make it useful in treating or preventing conditions like heart attacks and strokes. Low dose aspirin ranges from 60 to 150 mg daily, but the usual dose taken during pregnancy to treat or prevent certain conditions is 81 mg daily.

What is an overdose of metoprolol?

Metoprolol is a moderately lipophilic β-blocker that in overdose causes direct myocardial depression leading to bradycardia, hypotension, and the potential for cardiovascular collapse. We describe the case of a 59-year-old man who intentionally ingested ~7.5 g of metoprolol tartrate.

What are the contraindications of metoprolol?

The following conditions are contraindicated with this drug.

Who should not take METOPROLOL SUCCINATE?

  • pheochromocytoma.
  • diabetes.
  • low blood sugar.
  • depression.
  • myasthenia gravis, a skeletal muscle disorder.
  • complete heart block.
  • second degree atrioventricular heart block.
  • sick sinus syndrome.

How many milligrams of metoprolol is fatal?

The two fatal overdose levels were deter- mined to be 50 mg/L in blood and 120 mg/kg in liver (6), and 56 mg/L in blood, 42 mg/L in vitreous humor, 276 mg/L in bile, and 260 mg/kg in liver (7). Several analytical procedures for the determination of metoprolol in biological specimens have been reported (8-13).

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